Figure 8
Panx3 signaling pathway in keratinocyte differentiation. Schematic representation of Panx3 signaling pathway in keratinocyte differentiation. 1) ATP releasing Panx3 channel activates Akt signaling in autocrine or paracrine manner. 2) Panx3 ER Ca2+ channel opened by Akt signaling promotes calmodulin (CaM)-NFAT signaling by raising up intracellular Ca2+ levels. 3) Dephosphorylated NFATc1 (active form NFATc1) enters the nucleus and binds to the promoter regions of Epfn. Epfn then promotes Nocth1 expression.
