Figure 6
From: CD117/c-kit defines a prostate CSC-like subpopulation driving progression and TKI resistance
Inhibition of CD117 decreased proliferation and sphere formation. Sorted C4-2 CD117+ cells were treated with the broad tyrosine kinase inhibitors imatinib and sunitinib, as well as, ISCK03, a CD117-specific inhibitor. (A) Proliferation was measured by live-cell imaging and represented as mean percent confluence ± SEM (n = 6). (.) Sphere formation was tracked using live-cell imaging and represented as mean sphere area (n = 12). ***Represents p < 0.005 by one-way ANOVA.
