Figure 3 | Scientific Reports

Figure 3

From: PMCA4 inhibition does not affect cardiac remodelling following myocardial infarction, but may reduce susceptibility to arrhythmia

Figure 3

PMCA 4 global deletion may protect against acute arrhythmic events post-MI. (A) Representative TTC stained sections from wildtype and PMCA4−/− hearts 2 days post MI. Images were acquired using a Leica S6D microscope with Leica MC170 HD camera, and Leica application suite EZ software. (B) Quantification of area at risk 2 days post-MI. WT n = 9, PMCA4−/− n = 11. (C) Representative 3 lead ECG traces from wild type and (D) PMCA4−/− mice day 1 post-MI. Premature contractions are indicated by #. (E) Percentage of mice displaying arrhythmia (black segments) upon ECG examination day 1 post MI. WT sham n = 8, WT MI n = 18, PMCA4−/− sham n = 8, PMCA4−/− MI n = 16 * p < 0.05.

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