Figure 7 | Scientific Reports

Figure 7

From: PMCA4 inhibition does not affect cardiac remodelling following myocardial infarction, but may reduce susceptibility to arrhythmia

Figure 7

PMCA 4 deletion from fibroblasts does not affect cardiac structure or function post-MI. (A) Kaplan–Meier survival plots for PMCA4flox/flox (black) and PMCA4fko mice (blue) followed for 6 weeks post MI (solid lines) or sham (dashed lines) surgery. Starting populations: control sham n = 6, control MI n = 13, PMCA4fko sham n = 6, PMCA4fko MI n = 12. (B) Ejection fraction and (C) Diastolic left ventricular diameter tracked for 6 weeks post-MI or sham surgery by echocardiography. #p < 0.05 versus sham control at matched time point (D) Heart weight/tibia length ratio 6 weeks post-MI or sham surgery. (E) dP/dt max and (F) dP/dt min 6 weeks post MI or sham surgery. control sham n = 6, control MI n = 12, PMCA4fko sham n = 6, PMCA4fko MI n = 11.

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