Figure 9 | Scientific Reports

Figure 9

From: PMCA4 inhibition does not affect cardiac remodelling following myocardial infarction, but may reduce susceptibility to arrhythmia

Figure 9

Treatment with PMCA 4 specific inhibitor does not affect cardiac structure or function post-MI. (A) Kaplan–Meier survival plots for mice subjected to sham surgery (black), or left anterior descending coronary artery ligation with vehicle (light grey) or PMCA4 inhibitor ATA treatment (dark grey) followed for 6 weeks post MI. Starting populations: sham n = 10, MI + vehicle n = 24, MI + ATA n = 29. (B) Left ventricular ejection fraction and (C) End diastolic volume 6 weeks post-MI or sham surgery as measured by echocardiography. (D) Heart weight/body weight ratio 6 weeks post-MI or sham surgery. (E) Mean myocyte cross sectional area 6 weeks post-MI or sham surgery. (F) Infarct size 6 weeks post MI. sham n = 10, MI + vehicle n = 20, MI + ATA n = 22 * p < 0.05.

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