Figure 7 | Scientific Reports

Figure 7

From: Metformin exerts anti-cancerogenic effects and reverses epithelial-to-mesenchymal transition trait in primary human intrahepatic cholangiocarcinoma cells

Figure 7

Changes of cell morphology after exposure to Metformin 10 µM for 57 days was observed in Large and Small duct-type iCCA by IF analysis. In both Large and Small duct-type iCCA, significant changes of cell morphology after exposure to Metformin 10 µM for 57 days, was observed. Indeed, treated cells displayed smaller nuclei, smaller total cell area and a smaller nucleus area / total cell area ratio compare to controls; these changes being consistent with a trend toward Mesenchymal-Epithelial transition34. *p < 0.05 versus controls. Data represent mean ± SD of N = 3 independent experiments.

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