Figure 2 | Scientific Reports

Figure 2

From: Influence of energy deficiency on the subcellular processes of Substantia Nigra Pars Compacta cell for understanding Parkinsonian neurodegeneration

Figure 2

Oscillations in intracellular molecular concentrations in relation to the oscillations of the membrane potential. (A) Oscillations in the membrane potential (V) and the corresponding variations of intracellular sodium (Na+), potassium (K+) and calcium (Ca2+) concentrations, (B) Oscillations in cytoplasmic (CP), endoplasmic reticulum (ER) and mitochondrial (MT) calcium concentrations and calcium-binding proteins (CBP—Cam & Calb) concentration in relation to the variation of the membrane potential, (C) Oscillations in cytoplasmic (CC), vesicular (VC) and extracellular (EC) dopamine (DA) concentrations in relation to the membrane potential, (D) Oscillations in fructose-6-phosphate (F6P), glyceraldehyde-3-phosphate (GAP), pyruvate (PYR), lactate (LAC) and adenosine triphosphate (ATP) concentrations in relation to the membrane potential, (E) Energy consumption by different cellular processes in the SNc cell, (F) Range bar plot of extracellular DA concentration with respect to nRRP. Cam Calmodulin, Calb calbindin, conc concentration, mM millimolar, mV millivolt, ATP adenosine triphosphate, AP action potential propagation, VR vesicle recycling, DP DA packing, DA dopamine, ES endoplasmic reticulum calcium sequestering, PD protein degradation, nRRP number of readily releasable vesicle pool.

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