Figure 2

Twenty-one amino acid regions, centered on the missense variation, obtained from a multiple sequence alignment of protein sequences from human, chimpanzee, mouse, rat, dog, horse, bovine, frog, and chicken, where available. (A) ABCA3, A1149V (c.446C > T); (B) ABCA3, V1057M (c.3169G > A); (C) ABCA3, V1399M (c.4195G > A); (D) CSF2RB, V105I (c.313G > A); (E) CSF2RB, R461C (c.1381C > T); (F) SCNN1B, R206W(c.616C > T); (G) SCNN1B, E468K (c.1402G > A); (H) SCNN1B, R624H (c.1871G > A); (I) SERPINA1, P393S (c.1177C > T); (J) SFTPA1, G98A (c.293G > C); (K) SFTPA1, N225K (c.675C > G); (L) SFTPC, H59R (c.176A > G); (M) SFTPC, T158M (c.473C > T).