Table 2 Neurological outcomes in the HDP and non-HDP groups in univariate and multivariate analyses.

From: Mortality and neurological outcomes in extremely and very preterm infants born to mothers with hypertensive disorders of pregnancy

Variables

HDP

Non-HDP

Crude OR (95% CI)

Adjusted OR (95% CI)

Model 1

Model 2

Model 3

Short-term outcomes

(n = 4,584)

(n = 4,584)

    

IVH (grade III or IV)

108/4.565 (2.4%)

157/4,565 (3.4%)

0.68 (0.53–0.87)

0.47 (0.35–0.63)

0.76 (0.58–1.00)

0.82 (0.61–1.09)

PVL

111/4,567 (2.4%)

181/4,568 (4.0%)

0.60 (0.48–0.77)

0.59 (0.45–0.78)

0.63 (0.48–0.81)

0.69 (0.52–0.90)

Neonatal seizures

63/4,577 (1.4%)

98/4,579 (2.1%)

0.64 (0.46–0.88)

0.40 (0.28–0.57)

0.59 (0.42–0.84)

0.61 (0.42–0.88)

In-hospital death

181/4,583 (3.9%)

140/4,582 (3.1%)

1.31 (1.04–1.63)

0.61 (0.47–0.80)

1.34 (1.04–1.72)

1.11 (0.85–1.44)

Medium-term outcomes

(n = 2,114)

(n = 1,969)

    

Cerebral palsy

112/1,845 (6.1%)

120/1,737 (6.9%)

0.87 (0.67–1.14)

0.70 (0.52–0.95)

0.89 (0.67–1.19)

0.92 (0.68–1.25)

DQ of < 70

216/1,344 (16.1%)

167/1,264 (13.2%)

1.26 (1.01–1.57)

0.93 (0.72–1.20)

1.34 (1.05–1.71)

1.18 (0.91–1.52)

Total death by 3 years of age

192/2,114 (9.1%)

159/1,969(8.1%)

1.14 (0.91–1.42)

0.59 (0.45–0.78)

1.21 (0.95–1.54)

1.02 (0.79–1.31)

  1. Data are given as n (%). Adjusted ORs were evaluated by multivariate analyses (models 1, 2, and 3). Bold text indicates a significant association.
  2. Model 1: diabetes mellitus or gestational diabetes mellitus, histological chorioamnionitis, administration of antenatal corticosteroid, mode of delivery, gender, and birth weight were included in the logistic regression model.
  3. Model 2: diabetes mellitus or gestational diabetes mellitus, histological chorioamnionitis, administration of antenatal corticosteroid, mode of delivery, and gender were included in the logistic regression model.
  4. Model 3: diabetes mellitus or gestational diabetes mellitus, histological chorioamnionitis, administration of antenatal corticosteroid, mode of delivery, gender, and SGA were included in the logistic regression model.
  5. HDP, hypertensive disorders of pregnancy; IVH, intraventricular haemorrhage; PVL, periventricular leukomalacia; DQ, developmental quotient; OR, odds ratio; CI, confidence interval; SGA, small for gestational age.