Table 3 Incremental cost per quality-adjusted life year (QALY) gained by vaccination for vaccine uptake rate 50% increase scenario.

From: An economic and disease transmission model of human papillomavirus and oropharyngeal cancer in Texas

Coverage strategy

Total cost*

Lost-QALYs

Incremental cost

Lost-QALYs difference

$/QALY

Base case vaccine cost: $178.14; intervention cost: $50.64 for the first dose; $20.26 for the second dose

Baseline

$6,865,857,562

1,281,115

   

50% increase over current rate for females

$13,531,356,911

1,228,503

$6,665,499,349

52,612

$126,689.20

50% increase over current rate for males and females

$20,219,433,083

1,157,743

$6,688,076,172

70,760

$94,517.75

Best case vaccine cost: $142.512; intervention cost: $20.26 for the first dose; $20.26 for the second dose

Baseline

$6,082,500,600

1,281,115

   

50% increase females

$9,856,665,333

1,228,503

$3,774,164,732

52,612

$71,734.45

50% increase males and females

$13,657,816,653

1,157,743

$3,801,151,321

70,760

$53,718.93

Worst case vaccine cost: $217.11; intervention cost: $87.92 for the first dose; $20.26 for the second dose

Baseline

$7,722,695,466

1,281,115

   

50% increase females

$17,933,089,043

1,228,503

$10,210,393,577

52,612

$194,065.98

50% increase males and females

$28,157,746,183

1,157,743

$10,224,657,141

70,760

$144,497.70

  1. (1) Discount rate is 0.03; (2) Costs reported in 2018 USD; (3) Planning horizon is 100 years; (4) Female and male vaccination includes age 13 to 26 years.
  2. *Note that "Total cost" denotes the sum of vaccination cost, promotion cost and treatment cost.