Figure 1
From: Co-administration of lipopolysaccharide and d-galactosamine induces genotoxicity in mouse liver
HE staining indicating LPS/D-GalN-induced liver damage. (A) Acute treatment. Mice were injected with LPS/D-GalN (25 μg/kg + 250 mg/kg, 25 μg/kg + 500 mg/kg and 50 μg/kg + 500 mg/kg body weight). After 6 h, HE staining was used to show the lesions of the liver in mice. (B) Chronic treatment: mice were injected with LPS/D-GalN (10 μg/kg + 100 mg/kg body weight) every other day for 8 weeks. Then HE staining was used to show the lesions of the liver in mice. Saline solution (0.9%) and cyclophosphamide (CTX) (50 mg/kg body weight) were used as negative and positive control, respectively. Original magnification: ×400.
