Figure 1
From: Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway
AT-1 sTg and AT-1S113R/+ display proteomic changes across secretory pathway-related processes. Proteins with significantly changing abundance and acetylation stoichiometry identified across secretory pathway-related KEGG pathways from liver fractions are shown in clusters (n = 4 WT; n = 4 AT-1 sTg; n = 4 AT-1S113R/+). Changes in proteome are indicated by a purple (AT-1 sTg), orange (AT-1S113R/+), or grey (neither proteome changed) circle; corresponding colored arrows indicate increase, decrease, or no change in proteome compared with WT. Acetylation stoichiometry changes are designated with a black arrow on the corresponding AT-1 model in which it changed significantly. If a site changes significantly in both models, the site is underlined.
