Figure 6
From: Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway
AT-1 sTg and AT-1S113R/+ display both divergent and convergent N-glycoproteomic changes across subcellular locations. (a) Euclidean distances comparing the distance between significant glycoforms found in AT-1 sTg and AT-1S113R/+ , broken down by sex and brain region. Distances were calculated according to their subcellular locations, with higher similarity indicated with dark colors. (b,c) Significant glycoprotein (b) and glycosite (c) overlap is examined at the level of model (AT-1 sTg v. AT-1S113R/+), brain region (cortex vs. hippocampus) and sex (female vs. male). The upper bar graph indicates the size of intersection and the left bar graphs shows total number of significant glycoproteins (b) or glycosites (c) in each dataset.
