Figure 1

DS-SARS-CoV-2 network. Molecular interaction network where the size of each node represents a HSA21 gene (bigger size), a HSA21 interactor (medium size, STRING score ≥ 900) or a non-HSA21 gene (smaller size) found consistently deregulated in DS. Circles represent the genes related to infection with SARS-CoV-2 as reported in WikiPathways, and squares are host proteins found in the SARS-CoV-2-Human Protein–Protein Interactome. Genes found consistently DE in at least 4 DS transcriptomic studies are colored depending on the tissue: in red when mainly DE in blood, yellow when mainly deregulated in brain, and orange when found in both blood and brain tissue. The gene ADAMTS1 is deregulated in blood but is also a pro-angiogenic factor upregulated in DS lungs (in purple)²⁹. The edges indicate a protein–protein interaction score (STRING score ≥ 215).