Table 1 Enriched KEGG pathways for DEGs between anagen and telogen.

Cytokine-cytokine receptor interaction

1.10E−11

CCL2, TNFSF12, LIF, CD40LG, IL10RA, TNFSF14, IL1F10, IL36RN, CD4, CCR2, CCR4, CCR7, IL1A, TNFSF13B, CSF2RB, CCL5, CSF1R, CCR10, THPO, CXCR3, INHBB, OSM, CXCR6, CCL14, IFNE, IL36G, TNFSF4, TGFB1, IL5RA, ACVRL1, IL2RB, IL7R, CD40, LTB, LTA, FASLG, TNFRSF1B, EPOR, IL2RA, BMP5, CXCL5, ACKR4, CCL19, IL21R, CLCF1, TNFRSF6B

PI3K-Akt signaling pathway

3.24E−07

PCK2, ITGA9, COL4A1, PDGFRB, CSF1R, LAMA2, ITGA5, ITGA11, LAMB2, FLT1, THBS4, THBS2, PIK3CG, PIK3R5, OSM, JAK3, FGF16, ANGPT4, IGF2, IGF1R, NOS3, ITGB7, IL7R, FASLG, COL4A2, TNC, LAMC3, KITLG, COL6A3, EPOR, IL2RA, IL2RB, FN1, ITGAV, F2R, EREG, CREB3L4, VWF, COL6A2, LPAR6

ECM-receptor interaction

7.52E−07

COL4A1, ITGA9, LAMA2, COL6A2, FN1, ITGB7, THBS4, HSPG2, THBS2, ITGA5, ITGAV, ITGA11, COL4A2, TNC, LAMC3, VWF, LAMB2, COL6A3

Cell adhesion molecules (CAMs)

9.32E−07

ITGA9, CDH15, CLDN15, NRCAM, CD34, CD4, CD226, CD2, L1CAM, CD40LG, CD86, ICAM1, ITGAL, CDH5, CDH4, CLDN7, ITGB2, ITGB7, CD40, CD8A, ITGAV, PTPRC, ITGAM, ESAM

Neuroactive ligand-receptor interaction

6.92E−06

PTH1R, CCK, GABRR2, CHRNA10, C5AR1, ADCYAP1, P2RX1, UTS2R, GPR35, MC4R, ADORA2B, CNR2, ADRB1, TAC1, RXFP2, P2RY10, ADRA2A, PTGER3, GAL, HRH2, C3, VIPR2, GRM2, TBXA2R, GRID2, OXT, PMCH, F2RL3, S1PR4, APLNR, C3AR1, DRD5, NPB, F2R, HCRTR1, LPAR6

Focal adhesion

8.17E−06

ITGA9, COL4A1, PDGFRB, LAMA2, ITGA11, LAMB2, FLT1, THBS4, THBS2, PARVB, PARVG, IGF1R, RAC2, ITGB7, SHC3, ITGA5, COL4A2, TNC, LAMC3, VWF, FN1, VAV1, ITGAV, COL6A3, COL6A2

NF-kappa B signaling pathway

1.86E−05

CD40LG, TIRAP, CD14, CCL19, CARD11, TNFSF14, CD40, LTB, LTA, ZAP70, ICAM1, PRKCQ, RELB, LYN, LAT, BTK, TNFSF13B

Rap1 signaling pathway

3.10E−05

RASGRP2, PDGFRB, APBB1IP, PLCB2, GNAI2, FLT1, ADORA2B, ARAP3, RAP1GAP, CSF1R, SIPA1, FGF16, ANGPT4, IGF1R, ITGB2, RAC2, LAT, LCP2, KITLG, ADCY4, VAV1, F2R, ITGAL, ITGAM, F2RL3

cAMP signaling pathway

0.000169188

NFATC1, ADCYAP1, ATP2A3, ADCY10, RAC2, GNAI2, ARAP3, ADRB1, CNGB3, CAMK4, PTGER3, VIPR2, NPR1, LIPE, OXT, CNGA3, PDE10A, ADCY4, VAV1, DRD5, F2R, CREB3L4, PDE4A, CFTR

MAPK signaling pathway

0.00685971

RASGRP2, NFATC1, RASGRP4, PDGFRB, TGFB1, IL1A, FLT1, CACNA1H, CSF1R, DUSP9, RELB, FGF16, ANGPT4, IGF2, IGF1R, RAC2, STK3, FASLG, KITLG, PTPN7, RPS6KA2, CD14, EREG

Calcium signaling pathway

0.006925474

ORAI2, TBXA2R, ADORA2B, NOS3, F2R, PLCB2, ADCY4, DRD5, CAMK4, PDGFRB, PTGER3, ITPKA, ADRB1, GNA14, HRH2, CACNA1H, P2RX1, ATP2A3

Ras signaling pathway

0.0081218

IGF2, RASGRP2, IGF1R, RAC2, RASGRP4, SHC3, PLA2G12B, CSF1R, FGF16, PLA2G2E, ZAP70, PLA2G2F, LAT, FASLG, KITLG, RASA3, PDGFRB, RASAL3, ANGPT4, FLT1

Protein digestion and absorption

0.01083711

COL15A1, SLC9A3, KCNQ1, COL5A3, KCNN4, COL13A1, COL4A2, COL4A1, COL24A1, COL6A3, COL6A2, SLC1A1

Arachidonic acid metabolism

0.011034945

PTGS1, TBXAS1, PLA2G12B, ALOX5, EPHX2, PTGIS, ALOX15, PLA2G2E, PLA2G2F, PTGES

Melanogenesis

0.014067417

WNT2B, ADCY4, PLCB2, CREB3L4, WNT3, WNT2, WNT9A, FZD9, WNT5B, KITLG, GNAI2

Hippo signaling pathway

0.014200591

WNT2B, TGFB1, BMP5, ITGB2, WNT3, WNT2, STK3, WNT9A, FZD9, DLG2, WNT5B, WTIP, SERPINE1, CTNNA3

cGMP-PKG signaling pathway

0.014896486

ADCY4, NFATC1, PLCB2, NOS3, NFATC4, NPR1, ATP2A3, KCNJ8, ADRA2A, PIK3CG, ADRB1, PIK3R5, CREB3L4, PDE2A, GNAI2

Phospholipase D signaling pathway

0.014927328

ADCY4, PDGFRB, FCER1G, FCER1A, SHC3, MS4A2, PLCB2, PIK3CG, F2R, PIK3R5, KITLG, LPAR6, CYTH4, GRM2

Wnt signaling pathway

0.021435141

WNT2B, NFATC1, PLCB2, NFATC4, RSPO4, WNT3, WNT2, LGR5, SOX17, RSPO2, WNT9A, FZD9, WNT5B, RAC2

Jak-STAT signaling pathway

0.025691752

IL7R, IL2RA, IL2RB, STAT4, SOCS1, IL10RA, PDGFRB, IFNE, IL21R, IL5RA, THPO, LIF, OSM, JAK3, CSF2RB, EPOR

Signaling pathways regulating pluripotency of stem cells

0.035422505

WNT2B, LIF, PCGF6, WNT3, WNT2, IGF1R, INHBB, DUSP9, JAK3, WNT9A, FZD9, WNT5B

Purine metabolism

0.049889538

ADCY4, PKLR, ENTPD2, NPR1, ADA2, AK5, PDE2A, PDE6A, ADCY10, PDE4A, PDE10A