Table 2 Baseline therapy and electrocardiographic, echocardiographic and coronary angiographic results of all patients, subgroups according to DES-generation and subgroups with above and below NT-pBNP median (2927 pg/ml, IQR 1282/8524).

From: Death is associated to the type of drug-eluting stent in patients with left ventricular dysfunction and elevated natriuretic peptide levels

 

All

n = 340

DES-generation

P-value

Above NT-pBNP median (> 2,927 pg/ml)

n = 170

Below NT-pBNP median (< 2,927 pg/ml)

n = 170

P-value

First-generation

n = 162

Newer-generation

n = 178

ACE-inhibitor/ARB; n (%)

340 (100)

162 (100)

178 (100)

–

170 (100)

170 (100)

–

Beta-bocker; n (%)

271 (80)

133 (82)

138 (76)

0.295

135 (80)

136 (80)

0.893

Aldosteron; n (%)

172 (51)

84 (52)

88 (49)

0.657

94 (55)

78 (46)

0.083

Aspirin; n (%)

340 (100)

162 (100)

178 (100)

–

170 (100)

170 (100)

–

Clopidogrel; n (%)

315 (93)

159 (98)

156 (88)

 < 0.001

161 (95)

154 (91)

0.146

Ticagrelor; n (%)

25 (7)

3 (2)

22 (12)

 < 0.001

9 (5)

16 (9)

0.146

Pacemaker, n (%)

28 (8)

17 (11)

11 (6)

0.148

17 (10)

11 (7)

0.237

ICD, n (%)

42 (12)

15 (9)

27 (15)

0.098

16 (9)

26 (15)

0.099

NT-proBNP (pg/ml) (n); median (IQR)

2,927 (1,282/8,524)*

2,776 (1,304/7,832)*

3,178 (1,177/9,214)*

0.425

8,498 (5,187/15,187) *

1,286 (558/2,059) ‡

 < 0.001

Total cholesterol (mg/dl); median (IQR)

175 (144/213)†

173 (146/208)*

177 (143/218)

0.520

167 (136/207)

181 (152/220)

0.002

HDL (mg/dl); median (IQR)

42 (35/50)

42 (34/50)

42 (35/49)

0.871

40 (35/47)

43 (34/53)

0.014

LDL (mg/dl); median (IQR)

89 (69/113)

87 (68/114)

89 (74/112)

0.705

87 (65/106)

95 (74/117)

0.716

Creatine (mg/dl); median (IQR)

1.12 (0.94/1.46)*

1.08 (0.93/1.36)

1.22 (1.00/1.54)†

0.018

1.32 (1.06/1.75)

1.03 (0.89/1.23)

< 0.001

eGFR, median (IQR)

58 (48/68)†

59 (48/68)‡

58 (46/69)‡

0.703

54 (41/65)

64 (54/72)

< 0.001

Sodium (mmol/l); median (IQR)

139 (137/141)

139 (137/140)

139 (137/141)

0.523

138 (136/141)

139 (137/140)

0.951

Potassium (mmol/l); median (IQR)

4.1 (3.8/4.4)

4.1 (3.8/4.3)

4.1 (3.8/4.4)

0.502

4.1 (3.7/4.5)

4.0 (3.8/4.3)

0.179

CRP (mg/dl); median (IQR)

1.41 (0.45/4.79)‡

1.08 (0.40/4.33)

1.94 (0.60/6.31)

0.488

2.43 (0.86/8.85)

0.81 (0.34/2.27)

< 0.001

D-Dimer (µg/ml); median (IQR)

0.95 (0.41/1.83)

0.75 (0.39/1.41)

1.13 (0.61/2.10)

0.996

1.32 (0.70/2.15)

0.51 (0.34/1.02)†

0.015

Fibrinogen (mg/dl); median (IQR)

481 (394/580)*

468 (393/559)‡

502 (404/585)†

0.482

515 (424/643)

449 (378/537)‡

< 0.001

Prothrombine time (%); median (IQR)

90 (75/106)

89 (75/104)

91 (75/107)

0.618

87 (71/103)

92 (77/107)

0.022

aPTT, (s); median (IQR)

38 (34/44)

38 (34/46)

37 (33/42)

0.031

39 (34/46)

37 (33/43)

0.425

INR; median (IQR)

1.2 (1.1/1.4)

1.2 (1.1/1.4)

1.3 (1.1/1.4)

0.708

1.3 (1.2/1.4)

1.2 (1.1/1.4)

0.035

Heart rate (bpm); median (IQR)

77 (66/88)

76 (66/91)

78 (66/85)†

0.061

80 (68/90)

75 (65/85)

0.006

Rhythm

   

0.221

  

0.067

Sinus rhythm; n (%)

292 (86)

139 (86)

153 (86)

–

138 (81)

154 (91)

–

Atrial fibrilation; n (%)

31 (9)

13 (8)

18 (10)

–

20 (12)

11 (6)

–

Other; n (%)

17 (5)

10 (6)

7 (4)

–

12 (7)

5 (3)

–

Ejection fraction; median (IQR)

33 (25/37) ‡

34 (29/38)

32 (22/37)

0.079

32 (24/37)

34 (29/38)

0.039

No. of coronary vessels diseased

*

*

 

0.045

 

‡

0.045

1 VD; n (%)

112 (33)

46 (28)

66 (37)

–

47 (28)

65 (38)

–

2 VD; n (%)

72 (21)

43 (27)

29 (16)

–

34 (20)

38 (22)

–

3 VD; n (%)

156 (46)

73 (45)

83 (47)

–

89 (52)

67 (40)

–

DES-generation

*

  

–

*

*

0.082

First-generation; n (%)

162 (48)

–

–

–

89 (52)

73 (43)

 

Newer-generation; n (%)

178 (52)

–

–

–

81 (48)

97 (57)

 
  1. ACE angiotensin-converting-enzyme, aPTT activated partial thromboplastin time, ARB angiotensin-receptor blocker, CABG coronary artery bypass graft, CRP C-reactive protein, DES drug-eluting stent, eGFR estimated glomerular filtration rate (Cockcroft-Gault formula), HDL high density lipoprotein, ICD implantable cardioverter-defibrillator, INR International Normalized Ratio, IQR interquartile range, LDL low density lipoprotein, NSTEMI non-ST-segment elevation myocardial infarction, NT-proBNP N-terminal proB-type Natriuretic Peptide, PCI percutaneous coronary intervention, VD vessel disease.
  2. Univariate predictor for death: *p ≤ 0.001; †p ≤ 0.010; ‡p ≤ 0.050.
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