Figure 3
From: Genetic deletion of Abcc6 disturbs cholesterol homeostasis in mice
Altered gene expression of cholesterol biosynthetic enzymes and apolipoproteins in Abcc6 knockout mice. (A) Relative hepatic gene expression levels of cholesterol biosynthesis enzymes [3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgcr), farnesyl pyrophosphate synthase (Fdps), farnesyl-diphosphate farnesyltransferase 1 (Fdft1), geranylgeranyl pyrophosphate synthase 1 (Ggps1) and lanosterol synthase (Lss)] and (B) apolipoproteins (Apoa1, Apoa2, Apoa4, Apob, Apoc1 and Apoe) of WT and Abcc6−/− mice (6-month-old: WT n = 22, Abcc6−/− n = 25; 12-month-old: WT n = 37, Abcc6−/− n = 39). Data are fold change of mean ± SD relative to samples of WT; by Student’s t test; *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001.
