Figure 3
From: Diet and companionship modulate pain via a serotonergic mechanism
Effect of enriched diet and companionship on levels of corticosterone in serum of male sickle mice. As described in Fig. 1(a–h) male mice were treated with regular or sickle diet in the absence or presence of a female companion for 3 weeks, and a group of male mice fed sickle diet in the presence of a companion upto 8 months of age were withdrawn (W) from sickle diet and the companion for 3 weeks. Blood was drawn after 3 weeks of treatments and after 3 weeks of withdrawal for corticosterone analysis. Regular diet without companionship, RD/C−, nSS = 9, nAA = 9; regular diet with companionship, RD/C+, nSS = 9, nAA = 9; sickle diet without companionship, SD/C−, nSS = 10, nAA = 9; sickle diet with companionship, SD/C+, nSS = 8, nAA = 9; withdrawn from sickle diet and companionship, W RD/C−, nSS = 9, nAA = 10; one-way ANOVA with Bonferroni’s post-hoc test, *p < 0.05, **p < 0.01, ***p < 0.001.
