Figure 2
From: Translational control of enzyme scavenger expression with toxin-induced micro RNA switches
Secondary structure and sequence of primary miRNAs targeting CYP1A2 without (top) and with (bottom) a theophylline aptamer in the basal segment. Design based on (a) miR-30a targeting the CYP1A2 sequence starting at nucleotide 325 or (b) naturally occurring miR-378a. Bulge sequences are highlighted by blue. Black arrows indicate predicted Drosha cleavage sites and white arrows indicate predicted Dicer cleavage sites. Restrictions sites are shown in blue. The mature miRNA sequences (guide strands) are shown in dark green and miRNA* (sense strands) in light green.
