Figure 3 | Scientific Reports

Figure 3

From: Development and characterization of patient-derived xenografts from non-small cell lung cancer brain metastases

Figure 3

Establishment of subcutaneous flank and orthotopic intracranial patient non-small cell lung cancer (NSCLC) brain metastasis xenografts. (A) Subcutaneous flank xenograft growth characteristics of University of Wisconsin (UW)-lung-2, UW-lung-5, UW-lung-16 and UW-lung-18 and UW-lung-21. Tumors were derived directly from patients’ tumors. (B) Representative MR images and histology of UW-lung-2 and UW-lung-16 orthotopic intracranial xenografts. Tumors were first passaged subcutaneously and then directly implanted into the brain. They were not passaged in culture. (C) Pictures of established cell lines UW-lung-2 (passage 20) and UW-lung-16 (passage 20). (D) Representative images of UW-lung-16 luciferase-expressing cells grown as orthotopic intracranial tumors.

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