Table 2 Effects of ADHD and ADGRL3 haplotypes on gray matter volume (Contrasts Patients < controls, Protective > other haplotypes, and Patients with Risk > or < Controls with other haplotypes, did not returned significant results).
Peak MNI | Peak t-value | Cluster size | Cluster breakdown | ||
|---|---|---|---|---|---|
Gray matter decreases in individuals with protective haplotypea,b | |||||
Modulated | R supramarginal | 60, -20, 24 | 4.116 | 116 | R supramarginal (112) |
Gray matter increases in individuals with risk haplotypea,b | |||||
Unmodulated | Median cingulate | 4, − 2, 32 | 4.285 | 99 | Median cingulate (67) |
L precentral | − 30, − 14, 58 | 4.331 | 81 | L precentral (72) | |
Modulated | R inf. temporal | 52, − 18, − 38 | 4.668 | 197 | R inf. temporal (123) |
R mid. frontal | 38, 24, 30 | 3.563 | 76 | R mid. frontal (15) | |
L inf. frontal | − 42, 30, 28 | 3.734 | 72 | L inf. frontal (33) L mid. frontal (29) | |
Gray matter decreases in individuals with risk haplotypea,b | |||||
Modulated | L inf. temporal | − 56, − 52, − 12 | 4.004 | 269 | L inf. temporal (165) L mid. temporal (89) |
R fusiform | 40, − 58, − 20 | 3.549 | 100 | R fusiform (54) R cerebellum (39) | |
Gray matter increases in patients | |||||
Unmodulated: | L putamen | − 18, 8, − 4 | 3.613 | 61 | L putamen (13) |
Modulated: | L putamen | − 18, 6, − 2 | 3.678 | 53 | L putamen (10) |
Interaction: gray matter increases in patients with protective haplotypeb,c | |||||
Unmodulated | L mid. frontal | − 32, 22, 32 | 4.545 | 50 | L mid. frontal (9) |
Interaction: gray matter decreases in patients with protective haplotypeb,d | |||||
Unmodulated | L orbitofrontal | − 16, 16, − 24 | 3.787 | 98 | L orbitofrontal (29) L sup. temporal (22) L mid. temporal (16) |
L fusiform | − 34, − 78, − 16 | 3.956 | 71 | L fusiform (39) | |
L parahippocampal | − 18, − 32, − 10 | 3.920 | 54 | L parahippocampal (3) | |
Modulated | Precuneus | 2, − 50, 50 | 3.478 | 90 | Precuneus (90) |
