Table 2 Hazard ratio (HR) and 95% confidence (95% CI) intervals for coronary heart disease (CHD) in cancer survivors stratified by prediagnosis body mass index (BMI) categories.

From: Risk of coronary heart disease among cancer survivors with different prediagnosis body mass index

 

Pre-diagnosis BMI (kg/m2)

< 18.5

(n = 621)

18.5–22.9

(n = 5305)

23.0–24.9

(n = 3392)

 ≥ 25.0

(n = 4182)

Coronary heart disease

Cases per 1000 person-years

9.14

4.04

6.02

5.53

Adjusted HR (95% CI), Model 1a

1.88 (1.16–3.04)**

1 (reference)

1.59 (1.22–2.08)***

1.55 (1.19–2.00)**

Adjusted HR (95% CI), Model 2b

1.96 (1.19–3.22)**

1 (reference)

1.56 (1.17–2.09)**

1.50 (1.01–1.94)**

Adjusted HR (95% CI), Model 3c

1.97 (1.20–3.24)**

1 (reference)

1.51 (1.13–2.01)**

1.38 (1.04–1.84)*

  1. Data above are presented in numbers, HR, and HR (95% CI).
  2. HR hazard ratio, CI confidence interval, BMI body mass index, CHD coronary heart disease, NSAIDs non-steroidal anti-inflammatory-drugs, ICD international classification of diseases, NC not calculable.
  3. NOTE: Coronary heart disease includes ICD-10 codes I20-I25.
  4. aCalculated from Cox proportional hazards model adjusted for socioeconomic factors (age, sex, residential area, insurance premium).
  5. bAdjusted for lifestyle (smoking status, alcohol consumption, and physical activity), medical characteristics (fasting serum glucose, total cholesterol, systolic blood pressure, and Charlson comorbidity index), and family history (cardiovascular disease) in addition to the variables included in Model 1.
  6. cAdjusted for depression and medication use (aspirin, statin, anti-hypertensive drugs, anti-diabetic drugs, and NSAIDs).
  7. Depression was defined as outpatient visit or hospital admission with claims code for major depression disorder/major depression disorder, recurrent (ICD-10 codes: F32 and F33).
  8. *p < 0.05, **p < 0.01, ***p < 0.001.
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