Table 1 Clinical and biochemical characteristics according to OPG levels.

From: Osteoprotegerin is a marker of cardiovascular mortality in patients with chronic kidney disease stages 3–5

 

OPG ≤ 10.08 pmol/L (n = 85)

OPG > 10.08 pmol/L (n = 60)

p value*

Age (years)

55.0 ± 15.2

64.4 ± 13.0

 < 0.001

Gender (male)

57 (67.1)

32 (53.3)

0.119

Diabetes (yes)

23 (27.1)

20 (33.3)

0.462

Dialysis (yes)

36 (42.4)

55 (91.7)

 < 0.001

Hemodalysis (yes)

19 (22)

17 (28)

0.439

Peritoneal Dialysis (yes)

17 (20)

38 (63)

 < 0.001

CVD

14 (16.5)

17 (28.3)

0.102

Hb (g/dL)

12.3 ± 2.0

11.1 ± 2.1

0.001

Albumin (g/dL)

4.2 ± 0.6

3.7 ± 0.6

0.001

P (mg/dL)

4.5 ± 1.7

4.8 ± 1.6

0.351

hsCRP (mg/dL)

5.5 ± 7.6

10.6 ± 14.7

0.017

IL-6 (pg/mL)

5.7 ± 11.9

10.4 ± 13.6

 < 0.001

TNF-a (pg/mL)

16.9 ± 6.1

19.5 ± 9.3

0.063

PTX3 (pg/mL)

4.0 ± 2.4

6.1 ± 7

0.001

Fetuin (pg/mL)

0.43 ± 0.10

0.40 ± 0.11

0.109

FGF-23 (pg/mL)

4273 ± 11,106

5013 ± 12,023

0.019

S100A (ng/mL)

63.6 ± 74.4

101.8 ± 96.3

0.008

sRAGE (pg/mL)

1981 ± 1214

2577 ± 1124

 < 0.001

Troponin I (ng/mL)

0.07 ± 0.07

0.19 ± 0.29

 < 0.001

Diastolic dysfunction

52 (61.2)

47 (78.3)

0.031

Ejection fraction > 45%

76 (93.8)

50 (89.3)

0.356

LV mass index (g/m2)

58.1 ± 16.6

68.0 ± 23.9

0.008

IMT mean (cm)

0.67 ± 0.21

0.85 ± 0.42

0.001

Death (all-cause)

13 (15.3)

43 (71.7)

 < 0.001

CV death

6 (7.1)

21 (35.0)

 < 0.001

  1. *Fisher exact test or Student’s t test; data of non-normal continuous variables were submitted to a logarithmic transformation; p < 0.05.
  2. Quantitative variables are expressed as mean ± standard deviation. Categorical variables are expressed as frequencies (percent).
  3. OPG, osteoprotegerin; Hb, hemoglobin; P, phosphate; hsCRP, high-sensitivity C-reactive protein; IL-6, interleukin-6; TNF-a, tumor necrosis factor alpha; PTX3, pentraxin-related protein; FGF-23, fibroblast growth factor 23; sRAGE, receptor for advanced glycation end products (RAGE) soluble form; LV, left ventricle; IMT, intima-media thickness; CV, cardiovascular.
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