Figure 7 | Scientific Reports

Figure 7

From: Computer modeling of whole-cell voltage-clamp analyses to delineate guidelines for good practice of manual and automated patch-clamp

Figure 7

V0.5 vs. amplitude plots and slope vs. amplitude plots of heterologously-expressed Nav1.5 currents recorded in COS-7 using manual patch-clamp. (A) Symbols represent the mean ± sem of pooled experimental values of V0.5 as a function of mean ± sem values of current amplitudes. Lines correspond to fit of computed values obtained from the kinetic model that has been optimized in Fig. 6 and in which RS has been set to 0, 2 and 5 M\(\Omega\) (compensated Cm = 20 pF). (B) Pooled experimental values of the activation slope as a function of mean ± sem values of current amplitudes.

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