Table 2 Comparison of intraretinal layer thickness and parafoveal and peripapillary vessel densities in patients and healthy controls.

From: Changes in parafoveal and peripapillary perfusion after decompression surgery in chiasmal compression due to pituitary tumors

 

Healthy controls (N = 44)

Patients (N = 62)

Comparison between preoperative values and healthy controls

Comparison between preoperative and postoperative values

Preoperative (N = 62)

Postoperative (N = 62)

Estimate (SE)

P value1

Estimate (SE)

P value2

VF (MD)

 

 − 8.03 ± 6.28

 − 3.34 ± 4.33

  

4.70 (0.74)

 < 0.0001

BCVA (logMAR)

 

0.14 ± 0.23

0.04 ± 0.08

  

 − 0.10 (0.03)

0.0003

pRNFL thickness (μm)

Average

100.24 ± 8.30

88.70 ± 11.60

85.40 ± 12.79

 − 11.20 (2.02)

 < 0.0001

 − 3.30 (0.77)

 < 0.0001

Temporal

77.45 ± 12.33

59.56 ± 14.54

59.66 ± 14.54

 − 17.38 (2.62)

 < 0.0001

0.10 (1.20)

0.9358

Inferior

129.00 ± 14.28

115.24 ± 17.90

111.26 ± 19.28

 − 13.34 (3.19)

0.0001

 − 3.98 (1.17)

0.0007

Nasal

71.43 ± 14.09

66.90 ± 12.10

63.18 ± 12.63

 − 4.91 (2.57)

0.0593

 − 3.73 (1.38)

0.0068

Superior

122.43 ± 13.31

113.10 ± 18.62

107.50 ± 21.32

 − 9.17 (3.30)

0.0066

 − 5.60 (1.47)

0.0001

GCIPL thickness (μm)

Average

84.29 ± 5.95

73.87 ± 7.93

73.82 ± 7.73

 − 10.61 (1.41)

 < 0.0001

 − 0.03 (0.39)

0.9467

Temporal

84.31 ± 6.14

78.27 ± 5.60

77.94 ± 7.06

 − 6.26 (1.17)

 < 0.0001

 − 0.31 (0.40)

0.4378

Inferior

81.67 ± 6.29

72.65 ± 8.03

72.03 ± 8.66

 − 9.20 (1.44)

 < 0.0001

 − 0.58 (0.43)

0.1749

Nasal

84.32 ± 5.71

70.65 ± 11.93

69.41 ± 12.47

 − 13.72 (1.91)

 < 0.0001

 − 1.19 (0.64)

0.0627

Superior

84.33 ± 6.58

73.00 ± 9.41

71.82 ± 10.53

 − 11.37 (1.65)

 < 0.0001

 − 1.16 (0.58)

0.0434

SRCP (%)

Average

48.62 ± 2.35

47.34 ± 2.06

45.95 ± 2.04

 − 1.22 (0.43)

0.0052

 − 1.40 (0.20)

 < 0.0001

Temporal

47.38 ± 2.91

47.23 ± 2.43

46.19 ± 2.57

 − 0.15 (0.53)

0.7809

 − 1.04 (0.33)

0.0014

Inferior

49.99 ± 3.45

47.93 ± 3.21

46.10 ± 3.25

 − 2.01 (0.65)

0.0027

 − 1.84 (0.37)

 < 0.0001

Nasal

47.62 ± 2.40

46.00 ± 2.80

44.73 ± 2.81

 − 1.57 (0.51)

0.0028

 − 1.27 (0.30)

 < 0.0001

Superior

49.48 ± 2.94

48.21 ± 2.77

46.77 ± 3.01

 − 1.14 (0.54)

0.0362

 − 1.44 (0.34)

 < 0.0001

DRCP (%)

Average

49.43 ± 2.20

48.75 ± 1.98

47.79 ± 2.24

 − 0.57 (0.40)

0.1572

 − 0.97 (0.31)

0.0017

Temporal

47.33 ± 2.90

47.31 ± 2.95

46.84 ± 2.72

0.07 (0.58)

0.9001

 − 0.47 (0.39)

0.2332

Inferior

51.49 ± 4.55

50.04 ± 3.51

48.55 ± 4.06

 − 1.34 (0.77)

0.0867

 − 1.49 (0.59)

0.0116

Nasal

48.32 ± 2.65

47.58 ± 3.12

46.80 ± 2.96

 − 0.64 (0.58)

0.2726

 − 0.79 (0.37)

0.0339

Superior

50.55 ± 3.12

50.07 ± 3.33

48.95 ± 3.32

 − 0.35 (0.64)

0.5897

 − 1.12 (0.45)

0.0121

RPC (%)

Average

58.32 ± 2.54

56.15 ± 4.77

54.58 ± 5.28

 − 2.00 (0.75)

0.0085

 − 1.57 (0.28)

 < 0.0001

Temporal

48.5 ± 5.39

43.98 ± 7.12

43.17 ± 7.31

 − 4.29 (1.15)

0.0003

 − 0.81 (0.56)

0.1493

Inferior

67.89 ± 5.63

67.67 ± 6.28

65.93 ± 7.69

0.03 (1.18)

0.9815

 − 1.74 (0.54)

0.0013

Nasal

50.72 ± 4.55

48.55 ± 6.26

46.61 ± 7.29

 − 2.32 (1.10)

0.0379

 − 1.95 (0.57)

0.0006

Superior

66.15 ± 4.33

64.39 ± 7.64

62.60 ± 7.32

 − 1.42 (1.25)

0.2586

 − 1.79 (0.67)

0.0075

  1. Significant values are indicated in bold.
  2. N numbers, VF visual field, MD mean deviation, BCVA best corrected visual acuity, pRNFL peripapillary retinal nerve fiber layer, GCIPL ganglion cell-inner plexiform layer, SRCP superficial retinal capillary plexus, DRCP deep retinal capillary plexus, RPC radial peripapillary capillary.
  3. *P values by linear regression with adjustment for age and spherical equivalent.
  4. †P values by generalized estimating equation analysis with adjustment for age and spherical equivalent.
  5. P value 1: linear regression analysis between preoperative patients and healthy controls.
  6. P value 2: linear regression analysis between preoperative and postoperative patients.
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