Figure 3 | Scientific Reports

Figure 3

From: MicroRNA‑331 inhibits isoproterenol‑induced expression of profibrotic genes in cardiac myofibroblasts via the TGFβ/smad3 signaling pathway

Figure 3

The miR‑331 expression alteration in the cardiac cells of mouse model and cultured cardiac myofibroblasts following ISO‑treatment. (A) RT‑qPCR results indicated that miR‑331 level has been reduced in the cardiac fibrosis tissues compared with the saline-treated tissues at days 3, 7, 14 and 28 (each group n = 5). (B) The miR‑331-5p relative expression has been downregulated in both ISO‑treated neonatal mouse and human cardiac myofibroblasts compared with the control group after 24 and 48 h. Assays were performed in triplicate. Means ± SEM was shown. The asterisk mark (*) represents a p value < 0.05.

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