Figure 6 | Scientific Reports

Figure 6

From: MicroRNA‑331 inhibits isoproterenol‑induced expression of profibrotic genes in cardiac myofibroblasts via the TGFβ/smad3 signaling pathway

Figure 6

Schematic representation of TGFβ pathway regulation by miR-331. In this model, miR-331 by targeting some genes (TGFβ-R1, TGFβ-1, SMAD2, and SMAD3) results in reduced TGFβ signaling pathway activity which in turn, effects the fibrotic genes expression of cardiac myofibroblasts and other related biological processes, including cell proliferation and migration.

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