Table 3 Covariates for CL screened by the stepwise method.

From: Population pharmacokinetic modeling and clinical application of vancomycin in Chinese patients hospitalized in intensive care units

Variable

F Test

F-change

P value

DA

/

5.3

0.022

DA, Cr

82.0

156.6

0.000

DA, Cr, VM

54.6

0.1

0.712

DA, Cr, Burn-S

56.4

3.9

0.050

DA, Cr, Burn-S, TBW

109.6

185.1

0.000

DA, Cr, Burn-S, TBW, CRRT-S

90.4

6.6

0.010

Final covariable equation: CL = 0.78 + 0.036*DA − 0.007*Cr − 0.43*Burn-S + 0.067*TBW + 0.41*CRRT-S

  1. Increases in the F value (F-change) represent the degree of influence of the addition of the corresponding covariate on CL (P < 0.05 retained the corresponding covariate; P > 0.05 deleted the corresponding covariate).
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