Table 4 Covariates for V screened by the stepwise method.

From: Population pharmacokinetic modeling and clinical application of vancomycin in Chinese patients hospitalized in intensive care units

Variable

F Test

F-change

P value

Cr

/

104.4

0.000

Cr, VM

53.1

1.6

0.210

Cr, age

66.5

22.5

0.000

Cr, age, NE

44.2

0.02

0.876

Cr, age, TBW

55.9

25.8

0.000

Cr, age, TBW, CRRT-S

41.9

0.3

0.563

Final covariable equation: V = 46.47 − 0.04* Cr − 0.07*Age + 0.16*TBW

  1. Increases in the F value (F-change) represent the degree of influence of the addition of the corresponding covariate on V. (P < 0.05 retained the corresponding covariate; P > 0.05 deleted the corresponding covariate).
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