Figure 1

Cohorts 1 and 2. Design of the study. (a–c) Cohort 1: In our previous study of this material¹⁶ the 101 individuals in this cohort were separated based on proteome patterns into two groups here called groups A and B. (a) The data of this cohort is considered as influenced by two “pseudofactors”: Group A versus group B and MS versus control, resulting in four combinations of group affiliation and MS status. The four categories of individuals led to a two-factorial design for analyses. The numbers of individuals in each category are indicated in circles. (b) Confidence intervals of differences between the groups were analysed within MS patients and within controls. (c) Confidence intervals of the differences between MS patients and controls were performed within both groups. (d and e) Cohort 2: In analogy to cohort 1, two groups were established. Group A are the IgG-negative individuals. (d) For this cohort three combinations of group affiliation and CIS status were present. (e) Confidence intervals of the differences in the proteome patterns between CIS and controls were performed within group A.