Table 2 Proteins selected by Martens’ uncertainty test²³ in the multivariate analysis PLS-DA for discrimination of MS/CIS versus controls with consistent negative regression coefficients in a model with 2 PLS factors.

From: Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis

Association Numbers	Gene names	Protein names	Regression coefficients^(a)		P values^(b)
Association Numbers	Gene names	Protein names	Cohort 1	Cohort 2	Cohorts 1 and 2
P04217	A1BG	Alpha-1B-glycoprotein	−0.015	−0.012	***
Q9P0K1	ADAM22	Disintegrin and metalloproteinase domain-containing protein 22	−0.012	−0.002	**
P05090	APOD	Apolipoprotein D	−0.007	−0.003	**
P02749	APOH	Beta-2-glycoprotein 1 (Apolipoprotein H)	−0.011	−0.004	***
P43251	BTD	Biotinidase	−0.015	−0.016	***
Q9NZP8	C1RL	Complement C1r subcomponent-like protein	−0.012	−0.011	***
P06681	C2	Complement C2	−0.012	−0.013	***
P01024	C3	Complement C3	−0.015	−0.006	***
P10643	C7	Complement C7	−0.008	−0.003	**
P00751	CFB	Complement factor B	−0.017	−0.010	***
P08603	CFH	Complement factor H	−0.007	−0.008	***
P05156	CFI	Complement factor I	−0.021	−0.008	***
P02452	COL1A1	Collagen alpha-1(I) chain	−0.005	−0.004	**
P08123	COL1A2	Collagen alpha-2(I) chain	−0.008	−0.002	**
Q16610	ECM1	Extracellular matrix protein 1	−0.021	−0.012	***
P02751	FN1	Anastellin	−0.021	−0.009
Q12841	FSTL1	Follistatin-related protein 1	−0.013	−0.007	***
P22692	IGFBP4	Insulin-like growth factor-binding protein 4	−0.014	−0.004	***
P01880	IGHD	Ig delta chain C region	−0.024	−0.011	***
O14498	ISLR	Immunoglobulin superfamily containing leucine-rich repeat protein	−0.015	−0.009	***
P19823	ITIH2	Inter-alpha-trypsin inhibitor heavy chain H2	−0.011	−0.012	***
Q08380	LGALS3BP	Galectin-3-binding protein	−0.004	−0.003	**
P40925	MDH1	Malate dehydrogenase, cytoplasmic	−0.025	−0.007	***
P13591	NCAM1	Neural cell adhesion molecule 1	−0.011	−0.001
O15394	NCAM2	Neural cell adhesion molecule 2	−0.021	−0.001	**
P19021	PAM	Peptidyl-alpha-hydroxyglycine alpha-amidating lyase	−0.020	−0.006	**
P30086	PEBP1	Hippocampal cholinergic neurostimulating peptide	−0.017	−0.005	**
P07225	PROS1	Vitamin K-dependent protein S	−0.003	−0.004	**
P41222	PTGDS	Prostaglandin-H2 D-isomerase	−0.002	−0.001	*
Q92932	PTPRN2	Receptor-type tyrosine-protein phosphatase N2	−0.009	−0.006	*
P02753	RBP4	Plasma retinol-binding protein (1–176)	−0.019	−0.006	***
P78509	RELN	Reelin	−0.012	−0.005
P07998	RNASE1	Ribonuclease pancreatic	−0.011	−0.010	***
Q9BZR6	RTN4R	Reticulon-4 receptor	−0.002	−0.008	*
Q86UN3	RTN4RL2	Reticulon-4 receptor-like 2	−0.021	−0.005	*
P35542	SAA4	Serum amyloid A-4 protein	−0.014	−0.007	***
O75326	SEMA7A	Semaphorin-7A	−0.020	−0.011	***
P08294	SOD3	Extracellular superoxide dismutase [Cu–Zn]	−0.004	−0.005	*
P02787	TF	Transferrin	−0.020	−0.006	***
Q15582	TGFBI	Transforming growth factor-beta-induced protein ig h3	−0.006	−0.012	**

^(a)Regression coefficients from PLS-DA within each cohort at two PLS factors.
^(b)FDR-adjusted p-values (presented by one, two or three stars for p > 0.05, p < 0.01 and p < 0001, respectively) based on univariate validation by two-way ANOVA of the combined data of 163 individuals from cohort 1, groups A and B (after omitting the effects of group affiliation by ER modelling) and cohort 2, group A. The data on 357 proteins analysed in both two cohorts were considered.

Back to article page

Table 2 Proteins selected by Martens’ uncertainty test²³ in the multivariate analysis PLS-DA for discrimination of MS/CIS versus controls with consistent negative regression coefficients in a model with 2 PLS factors.

Search

Quick links