Figure 3
Injection of the red blood cell (RBC) fraction, but not plasma, into the SA space activates BAT SNA and BAT thermogenesis, contributing to NF. (a) An example of the effects on BAT SNA and TBAT of injection of plasma or of red blood cells in the SA space (SAs). The injection of red blood cells, but not plasma, into the SAs elicited a prompt increase in BAT SNA and BAT thermogenesis (increase in TBAT). #The increases in BAT SNA and BAT thermogenesis elicited by either injection of red blood cells (n = 3) or blood (n = 3) in the SAs were blocked by the intracerebroventricular (icv) injection of the A1 adenosine receptor agonist, CHA (ntot = 6). (b) Group data showing the effect on BAT SNA and BAT thermogenesis resulting from insertion of the needle into the SA space (blue bars); injection of plasma into the SA space (orange bars); injection of RBC into the SA space (green bars); or injection of CHA icv (pink bars). (c) Time course of the effects on BAT SNA and TBAT following the insertion of the needle, or the injection of plasma or of RBC into the SA space. *p < 0.05.
