Table 1 The time course of the diagnostic values determined with ROC analyses.
Days after symptom onset | Total | Day3- | Day5- | Day7- | Day9- | Day11- | Day13- | Day15- | Day17- | Day19- | Day21- |
|---|---|---|---|---|---|---|---|---|---|---|---|
N | |||||||||||
RT-PCR positive | 186 | 186 | 183 | 174 | 165 | 147 | 120 | 86 | 67 | 54 | 43 |
RT-PCR negative | 144 | 72 | 66 | 54 | 37 | 28 | 18 | 15 | 13 | 9 | 8 |
Total | 330 | 258 | 249 | 228 | 202 | 175 | 138 | 101 | 80 | 63 | 51 |
IgM | |||||||||||
AUC | 0.948 | 0.944 | 0.944 | 0.942 | 0.925 | 0.910 | 0.931 | 0.927 | 0.917 | 0.875 | 0.849 |
[95% CI] | [0.918–0.969] | [0.893–0.972] | [0.888–0.973] | [0.874–0.975] | [0.829–0.969] | [0.786–0.966] | [0.800–0.979] | [0.762–0.980] | [0.717–0.980] | [0.605–0.969] | [0.544–0.964] |
Cutoff value [AU/mL] | 0.86 | 0.97 | 0.97 | 0.86 | 1.00 | 1.00 | 1.48 | 1.48 | 1.19 | 1.19 | 1.19 |
Sensitivity [%] | 93.0 | 90.9 | 91.8 | 95.4 | 94.6 | 95.2 | 91.7 | 94.2 | 100 | 100 | 100 |
Specificity [%] | 86.8 | 91.7 | 90.9 | 87.0 | 86.5 | 85.7 | 88.9 | 86.7 | 84.6 | 77.8 | 75.0 |
IgG | |||||||||||
AUC | 0.952 | 0.958 | 0.963 | 0.975 | 0.987 | 0.994 | 0.998 | 1.000 | 1.000 | 1.000 | 1.000 |
[95% CI] | [0.933–0.976] | [0.929–0.975] | [0.936–0.980] | [0.950–0.988] | [0.965–0.995] | [0.974–0.999] | [0.984–0.999] | N.A | N.A | N.A | N.A |
Cutoff Value [AU/mL] | 4.97 | 4.97 | 4.31 | 4.31 | 4.31 | 4.31 | 4.31 | 3.94 | 2.95 | 2.95 | 2.95 |
Sensitivity [%] | 88.2 | 88.2 | 90.2 | 93.1 | 95.8 | 97.3 | 99.2 | 100 | 100 | 100 | 100 |
Specificity [%] | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
