Table 3 Performance of MR parameters for diagnosing malignant salivary gland lesions.

Parameters	Threshold criterion	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)
Initial study (n = 42)
ADC (× 10⁻³ mm²/s)	≤ 1.516	100.0	29.0	33.3	100.0	47.6
TBF (mL/100 g/min)	≤ 105.96	100.0	32.2	34.4	100.0	50.0
APTSI (%)	> 1.779	72.7	64.5	42.1	87.0	66.7
ADC + TBF		100.0	61.2	47.8	100.0	71.4^a
ADC + APTSI		72.7	77.4	53.3	88.9	76.2^a
TBF + APTSI		72.7	77.4	53.3	88.9	76.2^a
ADC + TBF + APTSI		72.7	90.3	72.7	90.3	85.7^b
Validation study (n = 10)
ADC (× 10⁻³ mm²/s)	≤ 1.516	100.0	29.0	37.5	100.0	50.0
TBF (mL/100 g/min)	≤ 105.96	100.0	42.9	42.9	100.0	60.0
APTSI (%)	> 1.779	66.7	57.1	40.0	80.0	60.0
ADC + TBF		100.0	71.4	60.0	100.0	80.0
ADC + APTSI		66.7	71.4	50.0	83.3	70.0
TBF + APTSI		66.7	71.4	50.0	83.3	70.0
ADC + TBF + APTSI		66.7	85.7	66.7	85.7	80.0

ADC, apparent diffusion coefficient; TBF, tumor blood flow; APTSI, amide proton transfer related signal intensity; PPV, positive predictive value; NPV, negative predictive value.
^aSignificant difference in comparison with ADC alone or TBF alone (p < 0.05).
^bSignificant difference in comparison with each parameter (ADC or TBF or APTSI) alone (p < 0.05).

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