Table 2 Risk of Alzheimer’s disease according to BMI changes.

From: Body mass index trajectories and the risk for Alzheimer’s disease among older adults

 

Men

Women

Event

Duration

Unadjusted

HR (95% CI)

aAdjusted

HR (95% CI)

Event

Duration

Unadjusted

HR (95% CI)

aAdjusted

HR (95% CI)

N

Person-years

CIR

N

Person-years

CIR

2-year BMI changes

Decrease of > 15.0%

11

670

16.4

1.04 (0.58–1.89)

1.00 (0.55–1.82)

38

1034

36.8

1.64 (1.19–2.26)

1.51 (1.09–2.09)

Decrease of 10.1–15.0%

39

1865

20.9

1.34 (0.97–1.84)

1.21 (0.88–1.66)

91

2614

34.8

1.54 (1.25–1.91)

1.44 (1.17–1.79)

Decrease of 5.1–10.0%

220

11,682

18.8

1.20 (1.04–1.39)

1.14 (0.98–1.31)

335

12,653

26.5

1.17 (1.04–1.32)

1.14 (1.02–1.29)

Stable (± 5.0%)

1203

76,364

15.8

1.00

1.00

1,543

68,107

22.7

1.00

1.00

Increase of 5.1–10.0%

162

9869

16.4

1.05 (0.89–1.23)

0.95 (0.80–1.12)

240

10,728

22.4

0.99 (0.86–1.13)

0.94 (0.82–1.08)

Increase of 10.1–15.0%

35

1955

17.9

1.14 (0.82–1.60)

1.00 (0.71–1.40)

77

2485

31.0

1.37 (1.09–1.72)

1.17 (0.93–1.47)

Increase of > 15.0%

18

1034

17.4

1.11 (0.70–1.76)

0.88 (0.55–1.41)

43

1285

33.5

1.49 (1.10–2.02)

1.17 (0.86–1.59)

4-year BMI changes

Decrease of > 15.0%

19

1020

18.6

1.21 (0.77–1.90)

1.14 (0.73–1.80)

56

1360

41.2

1.92 (1.47–2.51)

1.68 (1.29–2.20)

Decrease of 10.1–15.0%

60

2782

21.6

1.39 (1.08–1.81)

1.33 (1.02–1.72)

126

3409

37.0

1.72 (1.43–2.06)

1.60 (1.33–1.92)

Decrease of 5.1–10.0%

245

13,426

18.2

1.18 (1.02–1.35)

1.13 (0.98–1.30)

405

13,592

29.8

1.38 (1.23–1.54)

1.31 (1.17–1.46)

Stable (± 5.0%)

1,071

68,805

15.6

1.00

1.00

1,354

62,410

21.7

1.00

1.00

Increase of 5.1–10.0%

200

12,803

15.6

1.00 (0.86–1.17)

0.96 (0.83–1.12)

284

12,723

22.3

1.03 (0.91–1.17)

0.98 (0.87–1.12)

Increase of 10.1–15.0%

69

3205

21.5

1.39 (1.09–1.77)

1.21 (0.94–1.55)

91

3716

24.5

1.13 (0.91–1.40)

1.00 (0.80–1.23)

Increase of > 15.0%

24

1398

17.2

1.11 (0.74–1.66)

0.88 (0.58–1.32)

51

1697

30.1

1.40 (1.06–1.85)

1.13 (0.85–1.50)

  1. BMI body mass index, CIR cumulative incidence rate, HR hazard ratio, CI confidence interval.
  2. aAdjusted for age, insurance premium, initial BMI, smoking status, alcohol consumption, regular exercise, hypertension, diabetes mellitus, and dyslipidemia.
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