Figure 4
Correlation between gene expression networks and the lipid mediator profile. (a) Correlation between modules detected by WGCNA (blue, green, and turquoise) and lipid mediator profile. Correlations between the gene expression profile and the lipid mediator profile, which was used as trait, were analyzed by WGCNA. Asterisks indicate lipid mediators that were significantly altered by MT relative to IVI. (b) Pathway mapping of lipid mediators in lung. The WGCNA correlation score of the blue (left column), green (middle column), and turquoise (right column) modules of detected lipid mediators were mapped on the metabolic pathway. Lipid mediators that were detected but not included in the WGCNA modules are indicated by small grey-filled squares. *P < 0.05 for IVI + MT versus IVI by Welch’s t-test with Bonferroni’s multiple comparisons.
