Table 4 Cox proportional hazard model of MFS, RFS, OS, and CSS in four pTN groups (A) among overall 4236 patients and (B) among only 1382 radical nephrectomized cases.

From: Prognostic significance of pathologic nodal positivity in non-metastatic patients with renal cell carcinoma who underwent radical or partial nephrectomy

Group

MFS (n = 4236, event = 141)

RFS (n = 4236, event = 410)

N

Event (%)

Univariable model

Multivariable model

N

Event (%)

Univariable model

Multivariable model

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

(A)

pT3-4N0

482

57 (11.8)

1 (ref)

 

1 (ref)

 

482

144 (29.9)

1 (ref)

 

1 (ref)

 

pT1-2N0

3702

80 (2.2)

0.17 (0.12–0.24)

< .001

0.32 (0.23–0.47)

< .001

3702

239 (6.5)

0.18 (0.15–0.22)

< .001

0.34 (0.27–0.43)

< .001

pT1-2N1

25

3 (12.0)

1.06 (0.33–3.39)

0.922

1.34 (0.41–4.33)

0.629

25

10 (40.0)

1.38 (0.73–2.63)

0.322

1.09 (0.51–2.35)

0.820

pT3-4N1

27

1 (3.7)

0.38 (0.05–2.72)

0.332

0.42 (0.06–3.09)

0.394

27

17 (63.0)

3.21 (1.94–5.30)

< .001

2.75 (1.53–4.96)

0.001

Group

OS (n = 4236, event = 351)

CSS (n = 4236, event = 212)

N

Event (%)

Univariable model

Multivariable model

N

Event (%)

Univariable model

Multivariable model

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

pT3-4N0

482

109 (22.6)

1 (ref)

 

1 (ref)

 

482

87 (18.1)

1 (ref)

 

1 (ref)

 

pT1-2N0

3702

221 (6.0)

0.25 (0.20–0.32)

< .001

0.48 (0.37–0.62)

< .001

3702

109 (2.9)

0.15 (0.12–0.20)

< .001

0.27 (0.20–0.37)

< .001

pT1-2N1

25

10 (40.0)

1.81 (0.95–3.46)

0.074

2.11 (1.05–4.26)

0.036

25

8 (32.0)

1.76 (0.85–3.64)

0.128

1.93 (0.83–4.51)

0.127

pT3-4N1

27

11 (40.7)

2.27 (1.22–4.22)

0.010

3.49 (1.73–7.05)

0.001

27

8 (29.6)

2.02 (0.98–4.17)

0.058

2.73 (1.26–5.93)

0.011

Group

MFS (n = 1382, event = 56)

RFS (n = 1382, event = 173)

N

Event (%)

Univariable model

Multivariable model

N

Event (%)

Univariable model

Multivariable model

HR (95% CI)

p valve

HR (95% CI)

p valve

HR (95% CI)

p valve

HR (95% CI)

p value

(B)

pT3-4N0

246

27 (11.0)

1 (ref)

 

1 (ref)

 

246

62 (25.2)

1 (ref)

 

1 (ref)

 

pT1-2N0

1108

26 (2.4)

0.18 (0.11–0.32)

< .001

0.31 (0.18–0.56)

< .001

1108

97 (8.8)

0.27 (0.20–0.38)

< .001

0.54 (0.36–0.79)

0.002

pT1-2N1

14

3 (21.4)

2.33 (0.75–7.23)

0.145

2.16 (0.69–6.77)

0.188

14

6 (42.9)

1.92 (0.83–4.44)

0.128

1.35 (0.57–3.18)

0.499

pT3-4N1

14

0 (0.0)

0.33 (0.02–5.78)

0.451

0.23 (0.01–4.10)

0.317

14

8 (57.1)

3.31 (1.58–6.91)

0.002

1.54 (0.70–3.36)

0.280

Group

OS (n = 1382, event = 140)

CSS (n = 1382, event = 84)

N

Event (%)

Univariable model

Multivariable model

N

Event (%)

Univariable model

Multivariable model

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

pT3-4N0

246

42 (17.1)

1 (ref)

 

1 (ref)

 

246

32 (13.0)

1 (ref)

 

1 (ref)

 

pT1-2N0

1108

88 (7.9)

0.36 (0.25–0.52)

< .001

0.64 (0.43–0.95)

0.028

1108

44 (4.0)

0.24 (0.15–0.38)

< .001

0.52 (0.31–0.87)

0.013

pT1-2N1

14

5 (35.7)

1.93 (0.76–4.88)

0.167

4.51 (1.57–12.98)

0.005

14

4 (28.6)

1.99 (0.70–5.64)

0.196

3.00 (0.87–10.30)

0.081

pT3-4N1

14

5 (35.7)

1.95 (0.77–4.94)

0.160

3.21 (1.1–9.41)

0.034

14

4 (28.6)

2.03 (0.72–5.75)

0.184

2.73 (0.92–8.08)

0.070

  1. (Panel A) Adjusted for hypertension, operative extent, histology, nuclear grade, and necrosis in multivariable model of MFS. Adjusted for BMI, ASA, hemoglobin, platelet, nephrectomy, operative extent, histology, nuclear grade, and necrosis in multivariable model of RFS. Adjusted for age, BMI, diabetes, hypertension, ASA, hemoglobin, nephrectomy, operative extent, nuclear grade, and sarcomatoid differentiation in multivariable model of OS. Adjusted for BMI, diabetes, hypertension, ASA, hemoglobin, nephrectomy, histology, and nuclear grade in multivariable model of CSS.
  2. (Panel B) Adjusted for nuclear grade and necrosis in multivariable model of MFS. Adjusted for ASA, platelet, nephrectomy, nuclear grade, sarcomatoid differentiation, and necrosis in multivariable model of RFS. Adjusted for age, BMI, diabetes, ASA, hemoglobin, nuclear grade, and sarcomatoid differentiation in multivariable model of OS. Adjusted for age, BMI, hemoglobin, creatinine, nuclear grade, sarcomatoid differentiation, and necrosis in multivariable model of CSS.
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