Table 1 Characteristics of ANRS12174 trial participants who subsequently enrolled in the M&S study by treatment group (N = 553).
LPV/r (n = 274) | 3TC (n = 279) | P value | |
|---|---|---|---|
Mother’s characteristics at randomization (day 7) | |||
Age (years) | 28.2 (24.6;32.6) | 27.8 (23.2;31.5) | 0.12 |
Parity | 3 (2;4) | 2(1;4) | 0.08 |
Pre-delivery CD4 counts (cells per uL) | 520 (425;654) | 517 (441;667) | 0.26 |
Undetectable plasma HIV-1 RNA | 123 (45.6)‡ | 132 (48.5)¤¤ | 0.49 |
WHO stage | 0.83 | ||
1 | 264 (96.4%) | 266 (95.3%) | |
2 | 10 (3.6%) | 12 (4.3%) | |
3 | 0 | 1 (0.4%) | |
Maternal PMTCT regimen | |||
During pregnancy | 264 (96.3%) | 265 (95.0%) | 0.43 |
During labour | 266 (97.1%) | 273 (97.8%) | 0.56 |
PMTCT treatment duration (weeks) | 9 (6;12) | 10 (6;12) | 0.44 |
Infant characteristics at randomization (day 7) | |||
Sex | 0.25 | ||
Male | 130 (47.4%) | 146 (52.3%) | |
Female | 144 (52.6%) | 133 (47.7%) | |
Birthweight (g) | 3000 (2800;3400) | 3100 (2800;3330) | 0.87 |
Infant characteristics at final (week 50) trial visit | |||
Breastfeeding duration (weeks) | 40.7 (33.2;44.9)† | 41.0 (34.9;45.6) | 0.20 |
Study treatment duration (weeks) | 42.4 (33.4;47.4) | 44.1 (36.9;48.9) | 0.04 |
Weight (kg) | 8.2 (7.5;9.1) | 8.5 (7.7;9.2)¤¤ | 0.04 |
Lenght (cm) | 71.4 (69.9;73.5)+ | 72.0 (70.2;73.5)++ | 0.09 |
WAZ | − 0.82 (− 1.70;0.01)µ | − 0.72 (− 1.59;0.30)¤¤ | 0.08 |
LAZ | − 1.10 (− 1.83;− 0.32)+ | − 0.97 (− 1.64;− 0.23)++ | 0.25 |
WLZ | − 0.48 (− 1.30;0.46)µ | − 0.27 (− 1.13;0.51)µµ | 0.15 |
Underweight (WAZ < − 2) | 43 (19.1%)¤ | 37 (16.2%)¤¤ | 0.41 |
Stunting (HAZ < − 2) | 49 (21.6%) + | 35 (15.0%)++ | 0.07 |
Wasting (WLZ < − 2) | 23 (10.2%)µ | 25 (11.0%)µµ | 0.80 |
Caregiver/household characteristics at M&S follow-up study | |||
The mother has died | 11 (4.0%) | 7 (2.5%) | 0.32 |
Mother’s BMI | 24.7 (21.4;29.7)£ | 23.7 (20.9;29.4)££ | 0.21 |
The mother is taking HIV ART | 163 (69.1%)¥ | 173 (68.7%)# | 0.92 |
Caregiver’s education (highest grade) | |||
None | 39 (14.2%) | 27 (9.7%) | 0.10 |
Any primary | 102 (37.2%) | 94 (33.7%) | |
Any secondary | 133 (48.6%) | 158 (56.6%) | |
The caregiver can read | 221 (80.7%) | 239 (85.7%) | 0.12 |
The caregiver can write | 219 (79.9%) | 241 (86.4%) | 0.04 |
Household socioeconomic score (quintiles) | |||
1 (poorest) | 58 (21.2%) | 53 (19.0%) | 0.78 |
2 | 51 (18.6%) | 59 (21.1%) | |
3 | 51 (18.6%) | 60 (21.5%) | |
4 | 58 (21.2%) | 53 (19.0%) | |
5 (least poor) | 56 (20.4%) | 54 (19.3%) | |
Number of adults living in household | 2 (2;3) | 2 (2;3) | 0.71 |
Number of children (5–18 years) living in household | 2 (2;3) | 2 (1;3) | 0.67 |
Number of children (< 5 years) living in household | |||
0 | 160 (58.4%) | 130 (46.6%) | < 0.001 |
1 | 84 (30.7%) | 128 (45.9%) | |
≥ 2 | 30 (10.9%) | 21 (7.5%) | |
Child’s characteristics at M&S follow-up study | |||
Age (years) | |||
5 | 100 (36.5%) | 111 (39.8%) | 0.65 |
6 | 160 (58.4%) | 152 (54.5%) | |
7 | 14 (5.1%) | 16 (5.7%) | |
School attendance of the child | |||
None | 53 (19.3%) | 48 (17.2%) | 0.20 |
Ever attended kindergarten or primary | 147 (53.7%) | 136 (48.8%) | |
Attended both kindergarten and primary | 74 (27.0%) | 95 (34%) | |
