Figure 2

Functional analysis of the gastrointestinal (GI) tract. (a) Large intestine dissected from WT and KO littermates at 20 days. (b) Entire GI tract dissected from WT and KO mice. Note the delayed stool located in the middle segment of the large intestine in the KO mouse. (c) Anal region of WT and KO mice with watery stool attached around the anus in the KO mouse. (d) Fecal characterization. Feces of WT mice are large in number and similar in size. In contrast, feces of KO mice are small in number and irregular in size. (e,f) Comparison of the weight and quantity of daily feces. Total fecal weight expelled by KO mice is similar; however, the quantity is significantly less than observed in WT mice. This corresponds to higher weight per grain of feces. *P < 0.05, NS not significant.