Table 3 Results Cox proportional hazard regression with the different outcome evaluations.

From: Intraarticular triamcinolone hexacetonide, stanozolol, Hylan G-F 20 and platelet concentrate in a naturally occurring canine osteoarthritis model

Variable

Wheight distribution

HVAS (p = 0.000)

CBPI

LOAD (p = 0.000)

Symmetry Index (p = 0.008)

Deviation (p = 0.024)

PSS (p = 0.412)

PIS (p = 0.000)

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

Age

0.91 (0.83–10.01)

0.074

0.95 (0.86–1.05)

0.314

1.13 (1.02–1.25)

0.024*

1.08 (0.97–1.21)

0.163

0.95 (0.86–1.06)

0.374

0.93 (0.83–1.04)

0.190

Body weight

  

1.02 (0.97–1.07)

0.509

0.98 (0.93–1.03)

0.378

0.99 (0.93–1.05)

0.770

1.02 (0.97–1.08)

0.479

0.99 (0.94–1.06)

0.941

Sex

Male

1.00

   

1.00

 

1.00

 

1.00

 

1.00

 

Female

1.09 (0.59–2.02)

0.763

0.88 (0.49–1.57)

0.657

0.31 (0.15–0.62)

0.001*

1.24 (0.64–2.38)

0.524

1.12 (0.61–2.08)

0.715

1.18 (0.63–2.21)

0.616

Treatment

 

0.002*

 

0.005*

 

0.003*

 

0.154

 

0.000*

 

0.000*

Control

1.00

   

1.00

 

1.00

 

1.00

 

1.00

 

HG

0.53 (0.27–1.04)

0.067

0.44 (0.22–0.88)

0.020*

0.27 (0.12–0.63)

0.002*

0.31 (0.12–0.78)

0.013*

0.07 (0.03–0.21)

0.000*

0.11 (0.04–0.28)

0.000*

PCG

0.20 (0.93–0.45)

0.000*

0.31 (0.15–0.62)

0.001*

0.26 (0.12–0.56)

0.001*

0.53 (0.24–1.16)

0.114

0.09 (0.03–0.24)

0.000*

0.31 (0.15–0.64)

0.001*

SG

0.39 (0.19–0.82)

0.012*

0.85 (0.44–1.66)

0.642

0.33 (0.14–0.77)

0.010*

0.57 (0.25–1.33)

0.195

0.08 (0.03–0.23)

0.000*

0.17 (0.07–0.37)

0.000*

THG

0.46 (0.22–0.96)

0.039*

0.43 (0.21–0.89)

0.023*

0.98 (0.93–1.03)

0.151

0.70 (0.31–1.59)

0.397

0.05 (0.02–0.14)

0.000*

0.09 (0.94–1.06)

0.000*

OFA score

 

0.831

 

0.179

 

0.026*

   

0.175

 

0.007*

Mild

1.00

   

1.00

 

1.00

 

1.00

 

1.00

 

Moderate

0.85 (0.45–1.58)

0.605

1.01 (0.57–1.80)

0.973

1.29 (0.68–2.47)

0.435

1.09 (0.58–2.03)

0.79

1.74 (0.95–3.19)

0.074

2.93 (1.50–5.70)

0.002*

Severe

1.11 (0.47–2.62)

0.811

2.21 (0.95–5.2)

0.67

3.46 (1.39–8.55)

0.007*

0.79 (0.25–2.5)

0.70

0.86 (0.29–2.5)

0.784

1.56 (0.49–4.92)

0.451

Variable

COI

Stiffness (p = 0.001)

Function (p = 0.000)

Gait (p = 0.000)

QOL (p = 0.033)

Total (p = 0.000)

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

P

HR (95% CI)

p

HR (95% CI)

p

Age

1.19 (1.05–1.35)

0.007*

1.09 (0.99–1.21)

0.093

1.27 (1.13–1.43)

0.000*

0.98 (0.88–0.11)

0.835

1.15 (1.04–1.26)

0.005*

Body weight

1.03 (0.97–1.09)

0.324

1.03 (0.97–1.09)

0.346

1.01 (0.96–1.07)

0.717

1.04 (0.99–1.10)

0.106

0.98 (0.93–1.05)

0.603

Sex

Male

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

Female

2.02 (0.99–4.09)

0.051

1.40 (0.74–2.67)

0.304

1.28 (0.67–2.45)

0.453

2.58 (1.33–5.01)

0.005*

1.79 (0.95–3.37)

0.071

Treatment

 

0.032*

 

0.000*

 

0.002*

 

0.303

 

0.012*

Control

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

HG

0.25 (0.09–0.64)

0.004*

0.09 (0.03–0.27)

0.000*

0.16 (0.06–0.42)

0.000*

0.45 (0.19–1.05)

0.064

0.41 (0.19–0.90)

0.026*

PCG

0.34 (0.15–0.79)

0.012*

0.40 (0.19–0.81)

0.011*

0.28 (0.13–0.61)

0.001*

0.55 (0.26–1.15)

0.113

0.28 (0.13–0.59)

0.001*

SG

0.41 (0.16–1.02)

0.054

0.27 (0.11–0.66)

0.004*

0.45 (0.19–1.03)

0.058

0.92 (0.45–1.85)

0.808

0.53 (0.24–1.14)

0.103

THG

0.34 (0.14–0.80)

0.014*

0.33 (0.15–0.73)

0.006*

0.32 (0.15–0.69)

0.004*

0.69 (0.32–1.47)

0.333

0.39 (0.18–0.85)

0.018*

OFA score

 

0.0159

 

0.014*

 

0.081

 

0.338

 

0.048*

Mild

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

Moderate

0.97 (0.49–1.89)

0.936

1.07 (0.54–2.14)

0.841

0.66 (0.34–1.28)

0.222

0.81 (0.44–1.47)

0.477

0.61 (0.33–1.15)

0.127

Severe

2.48 (0.94–6.59)

0.068

4.59 (1.65–12.82)

0.004*

2.11 (0.79–5.58)

0.134

1.75 (0.67–4.55)

0.252

2.17 (0.86–5.45)

0.101

  1. See Table 1 for legend.
  2. *Indicates significance.
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