Figure 3 | Scientific Reports

Figure 3

From: Pluripotency and immunomodulatory signatures of canine induced pluripotent stem cell-derived mesenchymal stromal cells are similar to harvested mesenchymal stromal cells

Figure 3Figure 3Figure 3

Response of ciMSCs, cAT-MSCs and cBM-MSCs to priming with pro-inflammatory cytokines canine tumor necrosis factor-α (cTNF-α), canine interferon-γ (cIFN-γ) and a combination of both (cTNF-α + cIFN-γ). When stimulated with cTNF-α, cIFN-γ, or a combination of both, ciMSCs upregulated their expression of : (A) iNOS; (B) GAL-9; (C) COX-2; (D) TGF-β; (E) PTGER-2α; (F) IDO; (G) HGF; (H) VEGF; (I) IL-8 and (J) IL-1β. Significance is defined as: ns = not significant p > 0.05; *p ≤ 0.05; **p ≤ 0.005; ***p ≤ 0.0002; ****p ≤ 0.0001.

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