Figure 5 | Scientific Reports

Figure 5

From: Pluripotency and immunomodulatory signatures of canine induced pluripotent stem cell-derived mesenchymal stromal cells are similar to harvested mesenchymal stromal cells

Figure 5

Effect of ciMSCs and cAT-MSCs on inflammatory cytokine expression of mitogen-stimulated canine lymphocytes. Lymphocytes cultured with ciMSCs and cAT-MSCs downregulated their expression of GAL-9, PTGER-2α and VEGF, while the expression of iNOS, IDO, IL-8 and IL-1β were unchanged. Lymphocytes co-cultured with cAT-MSCs increased their expression of COX-2 and TGF-β1. Significance is defined as: ns = not significant; p > 0.05; *p ≤ 0.05; **p ≤ 0.005; ***p ≤ 0.0002; ****p ≤ 0.0001.

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