Figure 6 | Scientific Reports

Figure 6

From: Pluripotency and immunomodulatory signatures of canine induced pluripotent stem cell-derived mesenchymal stromal cells are similar to harvested mesenchymal stromal cells

Figure 6

Effects of co-culture on the secretion of factors by lymphocytes, ciMSCs and cAT-MSCs. Lymphocytes, ciMSCs and cAT-MSCs produce IL-1β, IL-8, TGF-β1 and VEGF. Based on mRNA levels (see Figs. 5 and 6), the increase in IL-1β measured in the medium from co-cultures of cMSCs and lymphocytes is likely produced by the ciMSCs and cAT-MSCs rather than the lymphocytes. When similarly referenced to mRNA levels, cAT-MSCs and lymphocytes in co-culture upregulate their expression of IL-8 while ciMSCs do not. Significance is defined as: *p ≤ 0.05; **p ≤ 0.005; ***p ≤ 0.0002; ****p ≤ 0.0001.

Back to article page