Figure 2
From: Three-dimensional ultrastructure of giant mitochondria in human non-alcoholic fatty liver disease
Quantitative comparison of a range of common morphometric parameters obtained from normal- (n = 2451) and giant mitochondria (n = 2081). (A) Mean giant mitochondria surface area (9.51 ± 6.20 µm2) was 4 × greater relative to normal mitochondria (2.35 ± 1.26 µm2). (B) On average giant mitochondria volume (1.13 ± 0.97 µm3) was 4.7 × larger than normal mitochondria (0.24 ± 0.15 µm3). (C) Surface area-to-volume ratio was 17.4% reduced between giant mitochondria and normal mitochondria. (D) Mean giant mitochondria length measured 3.99 ± 1.68 µm versus 1.18 ± 0.59 µm in normal mitochondria. (E) On average giant mitochondria were ~ 20% wider than normal mitochondria (0.64 ± 0.24 µm vs. 0.55 ± 0.15 µm). (F) The frequency of giant mitochondria versus normal mitochondria ranged between 36 and 65%, with a combined average of 46% for all patients. For each parameter statistical significance using Student’s t-test, P =  ≤ 0.001. One-way ANOVA indicates a lack of inter-patient variability for the NM groups, P =  < 0.0001. Additional tabular and graphical data derived from each of the 16 cells analysed (4 cells/patient) is also available (Supplementary Data S2–S4). Legend: CS, Combined score of all patients.
