Figure 4
From: Transcriptome analysis of arterial and venous circulating miRNAs during hypertension
Elevated arterial circulating microRNAs might be potential biomarker for hypertension. (a,b) Overlaps of deregulated miRNAs from SHR-vs-JSHR comparison and SHR-vs-WKY comparison in venous blood samples (a) and arterial blood samples (b). The heatmap shows all of the shared miRNAs. Note that batch effect correction was applied to combine the expression profiles of SHR/WKY groups and that of the JSHR group (because JSHR was sequenced in another batch). As the result, the differentially expressed in this analysis should be differed from the previous SHR-vs-WKY comparison. Nevertheless, 9 miRNAs are shared with the previous analysis (8 from arterial blood and 1 from venous blood), and these 9 miRNAs are highlighted by red arrows aside the heatmaps. (c) Droplet digital PCR quantification of rno-miR-455-3p, rno-miR-181b-5p rno-miR-140-3p and rno-miR-493-5p in arterial plasma of 6 WKY, 6 SHR and 6 JSHR rats. *P < 0.05, ***P < 0.001.
