Table 2 Table summarizing the top three most impacted pathways by the most differentially expressed genes obtained through RNA-Seq analysis (Ratio > 1.5 on Vehicle-treated samples), according to the Reactome tool.

From: Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells

Top 3 pathways (Reactome)

Reactome pathway

Overlap

Adjusted p-value

Cell Cycle

61/462

7 x 10−48

RHO GTPase Effectors

28/255

4 x 10−19

DNA Repair

22/285

7 x 10−12

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