Table 2 Biochemical blood analysis.

From: Transient prenatal ruxolitinib treatment suppresses astrogenesis during development and improves learning and memory in adult mice

Blood profiles (reference range)^^

G1 (0 mg/kg)

G2 (1 mg/kg)

G3 (5 mg/kg)

G4 (10 mg/kg)

G5 (15 mg/kg)

G6 (30 mg/kg)

Alanine aminotransferase (ALT) (22–32 U/l)

31.33 ± 1.76

26.00 ± 1.53

35.33 ± 7.80

53.33 ± 25.10

76.00 ± 54.78

39.67 ± 8.21

Aspartate aminotransferase (AST) (40–60 U/l)

59.20 ± 4.25

67.97 ± 19.33

75.67 ± 7.68

33.33 ± 13.08

80.87 ± 69.97

81.30 ± 30.50

Total protein (47.5–52.0 g/l)

48.43 ± 1.73

50.83 ± 1.19

48.37 ± 0.32

48.13 ± 2.35

53.53 ± 2.58

47.20 ± 2.52

Bilirubin (0.17–0.83 mg/dl)@

0.73 ± 0.09

1.87 ± 1.52

5.77** ± 0.56

5.77** ± 1.01

2.27 ± 0.37

3.30 ± 0.91

Albumin (26–29 g/L)

29.30 ± 0.95

28.93 ± 0.32

27.60 ± 1.71

31.17 ± 2.26

35.37 ± 1.85

33.33 ± 1.24

Potassium (3.5–4.1 mmol/l)

23.27 ± 1.26

5.70*** ± 0.10

4.53*** ± 0.58

5.30*** ± 0.00

5.10*** ± 0.80

4.80*** ± 0.50

Sodium (143–148 mmol/l)

180.70 ± 4.91

182.30 ± 4.70

189.70 ± 7.86

193.30 ± 5.24

191.30 ± 6.77

217.00* ± 16.65

Chloride (107–111 mmol/l)

107.70 ± 1.76

104.00 ± 0.58

104.30 ± 2.73

98.00 ± 2.52

95.67* ± 3.76

99.00 ± 3.51

Phosphate (1.2–1.8 mmol/L)

3.63 ± 0.28

1.90*** ± 0.06

1.70*** ± 0.17

1.90*** ± 0.10

1.55*** ± 0.05

1.57*** ± 0.12

Blood Urea (9.27–12.09 mmol/l)

6.57 ± 0.20

7.30 ± 0.93

6.93 ± 0.82

9.23 ± 1.04

10.33 ± 1.91

8.87 ± 1.22

Creatinine (26.5–35.4 μmol/l)#

45.00 ± 10.26

17.33 ± 2.33

30.00 ± 2.31

46.33 ± 24.92

65.67 ± 34.17

32.67 ± 3.53

  1. ^^ these reference intervals for clinical biochemistry profiles were obtained from P90-P135 (n = 1486) C57BL/6 and C3HeB/FeJ female mice31, with exception to the profile labelled with @, which were obtained from 8-, 26- and 52-week old (n = 4, 7 and 8 per age group, respectively) C57BL/6 female mice32, whereas the profile labelled with # were obtained from inbred (n = 10) and outbred (n = 30) 4-week old female mice33. Italic readings are within the reference intervals. All values represent in mean ± SEM.
  2. * Denotes adjusted p < 0.05, ** denotes adjusted p < 0.01 and *** denotes adjusted p < 0.001 when compared to G1 (0 mg/kg) group (n = 3 per group, based on One-way ANOVA with Dunnett's multiple comparisons).
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