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The active site of PLpros contains a classic catalytic triad, composed of Cys–His–Asp, where Cys acts as nucleophile. (a) Unliganded catalytic center of the active site of PLproSARS (PDB: 2FE810). (b) Unliganded catalytic center of the active site of PLproCoV2 (PDB: 6W9C37).
