Figure 2 | Scientific Reports

Figure 2

From: Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2

Figure 2

Ebselen is buried deeper in PLproCoV2 than in PLproSARS. (a,b), Molecular surface representation of the multi-domain architecture of PLproSARS (PDB: 2FE810) (a) and PLproCoV2 (PDB: 6W9C37) (b) in complex with ebselen. (c,d), Stick representation of the interactions between ebselen and residues in the active site of PLproSARS (c) and PLproCoV2 (d) before covalent modification of cysteine residue. (e,f) Stick representation of the interactions between ebselen and residues in the active site of PLproSARS (e) and PLproCoV2 (f) after covalent modification of cysteine residue.

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