Figure 4 | Scientific Reports

Figure 4

From: Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2

Figure 4

Ebselen inhibits PLproCoV2 in the micromolar range. (a) Structure of ebselen. (b) Progress curves for the hydrolysis of Ub-AMC by PLproCoV2 without and in the presence of increasing concentrations of ebselen. The concentrations of Ub-AMC and PLproCoV2 were 500 nM and 10 nM, respectively, the concentration of ebselen is shown in the legend in μM. (c,d) PLproCoV2 (c) and PLproSARS (d) assay results for ebselen without incubation and after a 1-h incubation at 37 °C. Data points are plotted as the mean of n = 3 independent experiments, with each experiment having n = 1 independent samples. (e) Inhibitory activities of ebselen toward PLpro from SARS and CoV2.

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